Preheat the oven to 350°F (175°C). Grease a 9×5-inch loaf pan with a little butter or non-stick spray.

In a large bowl, whisk together the flour, sugar, baking powder, baking soda, and salt.

In a separate medium bowl, mix the orange juice, orange zest, melted butter, beaten egg, and vanilla extract until well combined.

Make a well in the center of the dry ingredients and pour in the wet mixture. Stir gently with a spatula just until the flour disappears. Do not overmix.

Gently fold in the cranberries. If using frozen berries, do not thaw them first.

Pour the batter into the prepared loaf pan and smooth the top with your spatula.

Bake for 55 to 60 minutes. The bread is done when a toothpick inserted into the center comes out clean or with just a few moist crumbs.

Remove the pan from the oven and let it cool for 10 minutes. Then, turn the loaf out onto a wire rack to cool completely before slicing.